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Purified recombinant protein of Rat interleukin 6 Il6
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The Recombinant Rat IL 6 Protein from R D Systems is derived from E coli The Recombinant Rat IL 6 Protein has been validated for the following applications Bioactivity
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Image Search Results
Journal: Brain research bulletin
Article Title: Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation
doi: 10.1016/j.brainresbull.2024.110889
Figure Lengend Snippet: IL-6 expression in the L4-L5 segments of spinal dorsal horn following VPA treatment. (A) and (C) represent each experimental design and time of tissue collection. (B) VPA down-regulated IL-6 expression in the L4-L5 segments of spinal dorsal horn induced by orofacial inflammation combined with FS stress. * P < 0.05 vs the CFA+FS+Saline group. (D) VPA did not affect the expression of IL-6 in the spinal dorsal horn of naïve rats. ns, non-significant.
Article Snippet:
Techniques: Expressing, Saline
Journal: Brain research bulletin
Article Title: Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation
doi: 10.1016/j.brainresbull.2024.110889
Figure Lengend Snippet: Intrathecal injection of rrIL-6 reversed anti-nociceptive effect of VPA on somatic hyperalgesia induced by orofacial inflammation combined with FS stress. (A) Experimental design for single injection of rrIL-6 and behavior tests of the thermal withdrawal latency and mechanical withdrawal threshold. (B) Experimental design for consecutive injection of rrIL-6 and timeline of the thermal withdrawal latency and mechanical withdrawal threshold. Rats were treated with VPA or saline intraperitoneally for 5 days, rrIL-6/saline were administered intrathecally 1 h after last VPA injection for single injection of rrIL-6 or 5 day consecutive injection of rrIL-6 after last FS. The behavioral tests for thermal withdrawal latency and mechanical withdrawal threshold were assessed before and after rrIL-6 injection. d, day; T, thermal withdrawal latency; M, mechanical withdrawal threshold; CFA, complete Freund’s adjuvant; FS, forced swim; VPA, valproate; rrIL-6, recombinant rat IL-6. (C, D) The mechanical withdrawal threshold (C) and thermal withdrawal latency (D) were significantly decreased after single injection of rrIL-6. (E, F) The mechanical withdrawal threshold (E) and thermal withdrawal latency (F) were significantly decreased after consecutive injection of rrIL-6. *, ***, **** P < 0.05, 0.001, 0.0001 vs pre-IL-6, respectively. # , ## , ### , #### P < 0.05, 0.01, 0.001, 0.0001 vs the CFA+FS+VPA+Saline group at the same time point, respectively.
Article Snippet:
Techniques: Injection, Saline, Adjuvant, Recombinant